Just like Restylane®, Perlane® is a dermal filler made of hyaluronic acid, a natural substance that already exists in the human body. The hyaluronic acid also creates volume and fullness in the skin, giving it a healthy, youthful appearance. It is used to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth. Perlane is similar to Restylane®, but it has a larger particle size.